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KMID : 0359420050230010064
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Korean Journal of Sports Medicine
2005 Volume.23 No. 1 p.64 ~ p.70
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Mutation of the β-3 Adrenergic Receptor Gene is Associated with Body Fat Distribution in Korean Adults
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Kim Ki-Jin
Lee Won-Jae
Lee Sun-Jang
Ahn Na-Young
Oh Hyang-Ran
Shin Yoon-Jung
Park Ju-Sik
Hong Chang-Bae
Kim Sang-Hyun
Kim Eun-Moon
Lee Jee-Eun
Kim Eun-Jin
Jang Ji-Seun
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Abstract
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In previous studies, β-3 adrenergic receptor is expressed in adipocytes and mediates the rate of lipolysis in response to catecholamines, so the Trp64Arg mutation in the β-3 adrenergic receptor gene has been associated the changes of body fat distribution and insulin sensitivity. Compared with subcutaneous fat, lipolysis in visceral fat is more sensitive to catecholamine stimulation, and Trp64Arg mutation has been associated with hyperinsulinaemia or features of insulin resistance. But these association could not accepted in different results. We could not find a significant the association of skinfold thickness and body circumferences with the Trp64Arg mutation of the β-3 adrenergic receptor gene in Korean adults. And blood leptin concentration, BMI, and WHR showed no significant differences between subjects with and without the Arg variant. We could not support any direct involvement of the Trp64Arg polymorphism of the β-3 adrenergic receptor gene in the development of body fat distribution in Korean adults.
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KEYWORD
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Body fat distribution, β-3 adrenergic receptor, Trp64Arg polymorphism
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